11-[Bis(trimethylsilyl)amino]-2,4-bis(trimethylsilyl)-7,8,9,10-tetrahydro-6H-cyclohepta[1,2-b]quinoline
نویسندگان
چکیده
منابع مشابه
Dibenzo[b,e]thiepin-11(6H)-one
In the title compound, C(14)H(10)OS, the seven-membered thiepin ring adopts a distorted boat conformation with the dihedral angle between the mean planes of the two fused benzene rings being 56.5 (1)°.
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Benzamides and nicotinamides represent classes of drugs that have experienced an unusually broad spectrum of clinical development in a number of therapeutic areas [1]. One of their principal targets is the nuclear DNAbinding protein poly(ADP-ribose) polymerase-1 (PARP1), which is activated by nicks in DNA during inflammation, ischemia, neurodegeneration, and cancer therapy. When over-activated,...
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The Canadian Common Drug Review (CDR) was established in 2003 to Abstract provide a single process for making formulary recommendations to most Canadian publicly funded drug plans. This paper considers the most common challenges faced by the CDR: (a) determining the effectiveness of a drug (particularly interpreting the importance of surrogate markers and changes in QOL measures); (b) the massi...
متن کاملEndopeptidase 24:11 activity in cerebral microvessels.
The cndothelial cells of cerebral microvessels constitute a major site o f the blood-brain barrier. This barrier has physical and 'enzymic' components which together maintain the metabolic environment of the central nervous system. Major peptidase activities in cerebral microvessels are thought to be due to angiotensin-converting cnzymc (ACE) [ I ] and aminopeptidase(s) [2]. Although these enzy...
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ژورنال
عنوان ژورنال: IUCrData
سال: 2017
ISSN: 2414-3146
DOI: 10.1107/s2414314617008884